One of the unfortunate complications of diabetes is wounds on the feet that are slow to heal. Open wounds pose the risk of infection, leading to more serious complications, including amputation. The reasons why wound healing slows in diabetics are numerous, including high blood sugar, vascular system damage (poor circulation), diabetic peripheral neuropathy, immune system deficiency, infection, and others.
Elevated homocysteine levels are a known contributor to cardiovascular disease and are believed to impair wound healing in diabetic patients. Those with wound healing issues typically have poor circulation in their feet and lower legs and have a reduced ability to build skin cells.